One of the oldest and most commonly used blood sugar lowering drugs is metformin (N, N-dimethylbiguanide). Having limited side effects, it has been used since the late 1950s as the first line of treatment in patients suffering from diabetes mellitus. It has also been reported to demonstrate pleiotropic action as an anticancer agent. In this study, different tablets of metformin were analyzed by Raman spectroscopy. These tablets, coming from the United States and the Philippines, contain different amount of metformin were compared. The effect of glipizide on the Raman spectra was also determined in one of the tablets. Results showed common peaks found in all samples with increased signals observed in tablets containing a higher amount of metformin. These peaks matched with that obtained using density functional theory (DFT) calculations. Lastly, reduction of the Raman signal was observed in tablets containing glipizide.

Raman spectroscopy of different metformin tablets

2019 Spring National Meeting

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