A series of ruthenium (II)-arene complexes of several derivatives of bipyridine and phenanthroline have been synthesized by employing a green and efficient protocol involving water as a solvent under sonication. The structures of all the complexes were elucidated by the analysis of spectroscopic data. The geometry of the chlorido and PTA complexes was further confirmed by DFT. The stability study in various solvents, specifically in the intracellular one was conducted. Most of the compounds presented here are displayed significant potency and selectivity against MCF7 and Hela cell lines compared to cisplatin and RAPTA-C. Our heteroatom-RuCl complex exhibited good anticancer profiles against a few human cancer cells. Interestingly, few complexes turned up to be highly fluorescent as it was depicted by the quantum yield values. Remarkably, [(<i>η6</i>-pcymene)RuCl(κ2-N,N-bpy)]Cl was identified as the most significant cancer theranostic   agents   in   terms   of   potency,   selectivity,   and   fluorescence   quantum   yield. Absorption and emission spectral studies reveal that the complexes interact with both BSA and calf thymus DNA through groove binding mode and interactive mode. Also to have a better understanding of the mechanistic action of a drug in receptor binding studies mainly on the  A3AR   receptor  in  glioma via  nanocarriers and   to  know  its  pharmacokinetics  and  thermodynamic mechanism involved in it.

Synthesis of novel organometallic scaffolds as target oriented anticancer drug for glioma

2019 Spring National Meeting

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