Antibiotic resistance is a serious public health problem, and there is a growing need for tools and strategies to slow or stop the evolution of antibiotic resistance. Sixteen small soil samples were gathered from the ancient Roman city of Pollentia near Alcudia on the Balearic Island of Mallorca. More than 250 actinomycete cultures were isolated from the soils on a variety of solid media. About 60 of the cultures have been randomly selected and grown on liquid culture medium. Extracts of the cultures were screened for activity against S. aureus, E. coli and P. ultimum. About 75% of these cultures showed biological activity in our assays. Several compounds have been isolated and purified. Structures of compounds with antibiotic activity are being characterized, and the bacteria will soon be identified from their 16S ribosomal RNA

Antimicrobial natural products from sncient actinomycete bacteria

2019 Spring National Meeting

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