Traditional chemotherapy targets rapidly developing cells in the human body, resulting in harsh side effects from the destruction of healthy cells alongside of the cancer cells. Delivery systems to target the therapies can diminish the negative side effects while improving treatment. Gold nanoparticles (AuNP) offer many unique advantages as a drug delivery vehicle, including being biologically inert, easily adaptable to various shapes and sizes, the ability to create a strong Au-thiol bond, and heating upon the absorption of near-infrared light. To this end, the characterization of the surface modification, purification, and temperature dependent release from AuNPs were investigated. Included in the characterization were the time and temperature dependence of the surface modification, centrifugation velocity and time for the purification, and time and temperature dependence on the release of a drug like payload. The results of this study give insight into details of AuNP functionalization and lay the ground work for further optimization of AuNPs as drug delivery vehicles.<br/>

Characterization of drug loading and release from gold nanoparticles

2019 Spring National Meeting

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