Sugar sensing molecules are important in biological systems for determination of blood glucose levels and monitoring of diabetes. Current methods of quantification of blood glucose have limitations such as inaccuracy, invasiveness, and cost. In the past thirty years, research has been directed towards fluorescent molecules as sugar sensors, especially derivatives of boronic acid. Boronic acid derivatives are popular because of their ability to reversely bind diol-containing compounds such as glucose and fructose. Our research involves synthesis of <i>meta</i>- substituted diboronic acids fluorophore with dibenzylideneacetone core via a base-catalyzed aldol condensation and related reactions. The resulting fluorophore will be analyzed for its fluorescent response to carbohydrates such as fructose, glucose and galactose.

Synthesis and analysis of <i>meta</i>- substituted diboronic acids for carbohydrate sensing

2019 Spring National Meeting

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Synthesis and analysis of meta- substituted diboronic acids for carbohydrate sensing