Multiple myeloma is the second deadliest blood cancer. Early detection, diagnosis, and treatment are critical to increase the survivability of multiple myeloma and associated amyloidosis.  This research evaluates the synthesis of a multi-functional graphene oxide-based nanomaterial and its efficacy for use in a colloidal assay for detection of multiple myeloma cells.  Both graphene and gold family nanomaterials exhibit excellent biocompatibility with demonstrated application in photothermal therapy, which enables selective destruction of targeted cells by infrared light.  Typically, graphene oxide (GO) is prepared under harsh conditions, employing high concentrations of heated acid.  This research investigates the preparation of GO using greener alternatives.  The GO is then hybridized with spherical and popcorn shaped gold nanostructures and functionalized with antibodies for multiple myeloma cancer cells.  These hybrid systems were characterized using dynamic light scattering, transmission electron microscopy, and UV-Visible, FT-IR,  Raman, and fluorescence spectroscopy.   The systems were evaluated for selective binding of multiple myeloma cells.  Selective killing of the targeted cells was achieved after exposure to infrared light and evaluated using an MTT assay.

Multifunctional graphene composites for targeted detection and destruction of multiple myeloma cancer cells

2019 Spring National Meeting

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