To advance cancer precision medicine, tumor-targeting molecules are needed to guide the cancer theranostic agents to tumors. Phage display has a potential to discover personalized tumor-homing peptides. Here we show that breast tumor-homing peptides could be selected by phage display and further employed to guide the cancer theranostic agents such as gold nanorods to tumors to achieve targeted breast cancer imaging and therapy. Specifically, we employed in vivo biopanning to discover an MCF-7 breast tumor-targeting peptide from a phage-displayed random peptide library. We then verified that this peptide could guide the phage particles or inorganic nanoparticles to tumors. Finally, we confirmed that cancer theranostic agents modified by the tumor-homing peptide could home to and penetrate deep into tumors, detect tumors through multimodal imaging, and destruct tumors through chemo-/photothermal combination therapy. Our work confirmed that the tumor-homing peptides discovered by phage display could enable the targeted delivery of cancer theranostic agents to tumors, precise detection of tumors by clinical imaging modalities, and selective destruction of tumors by combination therapy.<br/>

Targeted breast cancer imaging and therapy enabled by tumor-targeting peptides

2019 Spring National Meeting

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