The biggest problems with athletes is the misuse and over use of multiple drugs, shortening their lives and finally taking them completely, all because of the abuse of these drugs. Our work is focused in the development of new anti-doping methods using the advantages of nanotechnology to improve the time and the sensitivity for drug testing. Formation of the nanoparticles was achieved by the reduction of AgNO3 with NaBH4 and HAuCl4, and adding sodium citrate and polyethylene glycol (PEG). In this research, we study the interactions with caffeine and Human Growth Hormone (HGH) with different sizes of silver, gold and silver/gold bimetallic nanoparticles. Characterization of these nanoparticles was performed using UV-Vis absorption spectroscopy and Diffracted Light Scattering (DLS). We also continued with a microscopic analysis to study the effect of these nanoparticles on the form and size of the drug crystals. Caffeine and Human Growth Hormone (HGH) were used for interaction with Au, Ag and Ag/Au nanoparticles. Several sizes were obtained for Au nanoparticles; 23,32, 42, 47 and 87 nm. For Ag nanoparticles sizes were 25 and 40 nm. Interaction of caffeine and HGH with Au nanoparticles results in a blue shift of a few nanometers. Therefore, the present study indicates that the combination of the nanoparticles with the selected drugs may be applicable as a new anti-doping method.

Anti-doping method using nanoparticles for sport drugs detection

2019 Spring National Meeting

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