Charge-charge interaction is ubiquitously present in a variety of natural and synthetic soft matters (e.g. protein, DNA, gene delivery carrier, and ion-conducting membrane, etc.). They often play a dominant role in the structure and dynamics of soft matters. Understanding the effect of charge-charge interaction on the structural and dynamic outcome of ion-containing soft matters is important. This presentation will be focused on our recent work on the design, synthesis and investigation of solution self-assembly of sequence-defined ionic peptoid block copolymers in aqueous solution. The position and number of ionizable monomers along the polymer chain were systematically varied during synthesis to allow their effect on the solution structure to be revealed. Our first study has shown that the ionic micellar structure can be precisely controlled by the position and pattern of the ionizable monomers in the sequence-defined polymers. The aggregation number and micellar size can be related to the position of the charged monomer by scaling relationships. Computational simulation of micellation also provided insights into the balancing act of charge-charge interaction and solvation of the charged monomers that dictate the micellar structure. Results from the study of semi-dilute solution of ionic peptoid block copolymers containing interacting micellar particles will also be discussed.<br/><br/><b>Figure 1</b>. Representative chemical structure of sequence-defined ionic peptoid block copolymer, sequence library and the cartoon depiction of micellar structures for sequence 1, 3, and 5.

Investigating the effect of charge-charge interaction on the solution self-assembly of sequence-defined ionic peptoid block copolymers

2019 Spring National Meeting

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