The unique recognition and complexation behavior of b-cyclodextrin and adamantane in aqueous solutions allow the creation of an ideal copolymer system that has both nucleic acid complexation and lectin targeting properties. Firstly, PDMAEMA with different chain length was initiated from b-cyclodextrin core to yield seven-arm star-shape polymers. In parallel, adamantane acrylate was copolymerized with pentafluorostyrene and dimethylacrylamide to afford a water-soluble copolymer, followed by a click reaction of <i>para</i>-fluorine with glucose units to obtain glycopolymers. Then the CD-adamantane complex formation of these two copolymers was monitored via 2D NOESY NMR and DLS. Finally, <i>in vitro</i> plasmid DNA delivery assays were conducted to investigate the gene delivery efficiency and specific targeting properties through the lectin-carbohydrate interaction. Results showed the successful complex formation in aqueous system and enhanced gene delivery efficiency of utilizing this system.

Cationic star-shaped glycopolymer brushes for targeted gene delivery

2019 Spring National Meeting

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