Singlet oxygen is an important reactive oxygen species which plays a prominent role in photodynamic therapy (PDT) treatment;on the other hand, singlet oxygen has been implicated in the genotoxicity of UV light. Therefore, efficient real-time detection of singlet oxygen is crucial for PDT and in biomedical research. In this presentation, we will discuss design of a new turn-on amplifying fluorescent polymer sensor for singlet oxygen detection based on a higher energy gap mechanism. At the core of the sensor is a tetracene-incorporating conjugated polymer. The reaction of tetracene unit with singlet oxygen creates a higher energy gap site within the conjugated backbone which acts to limit exciton migration length and increase fluorescent intensity. The design of this sensor is an excellent example of the versatility of the higher energy gap principle for the development of sensors for various practically important analytes.

Tetracene-based conjugated polymers for amplified fluorescent detection of singlet oxygen

2019 Spring National Meeting

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