Mesoporous silica nanoparticles are extensively studied materials in drug delivery because of their porous nature, stability, and biocompatibility. In this research, MCM-41 type mesoporous silica was studied for use as controlled drug release into the oral cavity. This was achieved through loading of the model dye toluidine blue into the pores of MCM-41 and coating the loaded particles with starch. The starch is digested by the salivary enzyme, α-amylase, allowing for controlled release into the oral cavity. After optimizing the dye loading procedure, the enzymatically mediated dye release of the starch coated particles was monitored over a three-hour period in the presence of and absence of α-amylase. The dye release rate increased in the presence of α-amylase, indicating the efficacy of these materials for enzymatically triggered drug release into the oral cavity.

Synthesis and characterization of biopolymer-capped mesoporous silica nanomaterials loaded with toluidine blue dye

2019 Spring National Meeting

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