A three-component reaction between γ-aryl-substituted α,β-unsaturated aldehydes and nitroakenes was realized by using cinchona alkaloid-derived (thio)ureas and squaramides as the catalysts. The reaction led to the formation of cyclohexenol derivatives with four contiguous stereogenic centers and a chiral substituent at the C2 position in high diastereoselectivities and ee values. The plausible mechanism of this new three-component reaction will be discussed.

Organocatalyzed three-component reaction of γ-arylenals and nitroalkenes

2019 Fall National Meeting

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