Stimulus-responsive drug delivery systems have emerged in large part in response to two common problems. Most drug delivery systems elute drug at relatively monotonic rates that are independent of the changing desires or needs of patients. Most intravascularly injected particles distribute themselves throughout the circulation, with off-target delivery causing toxicity.<br/><br/>Light is one of the most commonly-used stimuli used with triggerable drug delivery systems. Here we will explore selected methods by which light has been used to trigger drug delivery events in the body. One such type of event is triggered drug release, so that drug can be delivered on-demand, achieving a desired intensity and duration of effect determined by the intensity and duration of irradiation. Another is triggered targeting, where light is used to enhance the spatial accumulation of drug delivery systems in a desired locale, possibly enhancing the therapeutic index.<br/>

Photo-triggered drug delivery systems

2019 Fall National Meeting

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