Pharos is a web resource that originated from the NIH "Illuminating the Druggable Genome" (IDG) program to characterize the understudied regions of the druggable genome. These so-called “dark” regions are important because they have potential druggable opportunities toward a wide range of disease areas. Part of the IDG mandate is to move from simply gathering and displaying target data to generating data about understudied targets and therefore contribute to the illumination of dark targets. It is important that Pharos not only be able to display current data available, but to also be extendable and configurable to adapt to a variety of new data that is generated. The current version of Pharos collates datasets ranging from expression data to publications. The newest update of Pharos is a ground up UI rewrite designed to speed up the responsiveness of the site, as well as display newly generated data from our collaborators, ranging from data (imaging, phenotype, etc) to physical resources (knockout mice, cell lines, antibodies, etc). This update allows Pharos to be adapted to a wide range of data types, and positions Pharos to be a resource not only based on the dissemination of static target information, but to also produce resources and advance dark target knowledge which can then be utilized to further prioritize targets for drug discovery.

Pharos: Open-source target illumination platform

2019 Fall National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.