Research efforts inspired by the natural product UK-2A led to the development of carbohydrate-based macrocyclic picolinamides displaying potent in vitro and whole plant fungicidal activity. By means of utilizing available resources from the chiral pool, multiple synthetic routes were developed to identify which structural elements are requisite for effective binding at the METIII-Qi target site and translation of that activity to in vivo assays. The necessity of each synthetic approach and the biological impact of the resulting structural changes will be discussed.

Development of novel carbohydrate-based macrocyclic picolinamide fungicides

2019 Fall National Meeting

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