Continuous Manufacturing and Flow Chemistry are well-established at GSK. We operate a global network of continuous manufacturing facilities at lab, pilot and commercial scale to support delivery of our small molecule portfolio. In recent years there has been an increased focus on the commercial continuous manufacture of API, which requires a robust control strategy to ensure product quality and enable regulatory submission.<br/><br/>This presentation will outline GSK's approach to the development of control strategies for continuous manufacturing which has been followed for numerous projects nearing launch. Approaches to process design, modeling, parametric and operational controls will be discussed.

Enabling commercial continuous manufacturing through robust control strategies

2019 Fall National Meeting

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