Due to their potent insecticidal activity and low mammalian toxicity, pyrethroids, synthetic analogs of a botanical insecticide pyrethrum from Chrysanthemum species are used widely in the control of arthropod pests and human disease-transmitting insect vectors. These compounds exert toxic effects by modifying the function of voltage-gated sodium channels, which are critical for electrical signaling in the insect nervous system. However, due to extensive use of these compounds, many pest populations developed resistance to pyrethroids. One of the major mechanisms of pyrethroid resistance is known as knockdown resistance (kdr) resulting from mutations in the sodium channel gene. In this talk, I will give an update on the molecular mechanism of kdr in Aedes aegypti and present our recent results from the functional analysis of several new kdr mutations. Knowledge of kdr mutations and their roles in pyrethroid resistance provides a much-needed foundation for precision monitoring and management of pyrethroid resistance worldwide.

How many sodium channel mutations confer pyrethroid resistance in Aedes aegypti?

2019 Fall National Meeting

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