We isolated new lanthanide complexes with ligands containing thienyl groups to study their combined photophysical properties. When excited in the UV/vis, our compounds generate singlet oxygen (<sup>1</sup>O<sub>2</sub>), a reactive oxygen species, while displaying lanthanide-centered luminescence that enables fluorescence tracking. We evaluated them as potential candidates for photodynamic therapy (PDT) by studying their dark and light toxicity towards human cervical cancer cells (HeLa). The characterization of these lanthanide-containing photosensitizers, their cytotoxicity, and mechanism of action as assessed by flow cytometry and qRT-PCR will be discussed.

Exploring the dual properties of luminescent lanthanide complexes functionalized with singlet oxygen generators

2019 Fall National Meeting

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