Psychedelic drugs have earned newfound attention as treatments for some of society's most troubling medical problems - depression, anxiety, addiction and PTSD. The tryptamines found in so-called "magic mushrooms" (e.g. psilocybin, psilocin, etc.) are particularly attractive because they appear to offer immediate and long-lasting benefits without unwanted side-effects. This great promise has led political groups across the United States to seek legislative reform for "magic mushrooms".<br/>Despite their potential beneftis, the physical properties of these molecules have not been adequately studied. In this talk, we will present new developments regarding the purification, characterization, stability and chemical reactivity of psilocybin derivatives, including the first reported crystal structure of psilacetin fumarate, a readily attainable, cost-effective prodrug of psilocin.

Chemistry of psilacetin: Prodrug of psilocin

2019 Fall National Meeting

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