The global cannabis industry is growing rapidly, with many countries and US states adding regulatory frameworks for medical and adult-use cannabis programs.  Quality control is an essential component in protecting the health and safety of the consumer in this emerging market, and there is increasing demand upon cannabis testing laboratories for analytical determination of multiple cannabinoids.  As regulations evolve, and as research interests in minor cannabinoids expand, it is important to have robust analytical methods in place that are capable of meeting those needs.<br/> <br/>With these concerns in mind, HPLC method development toward the baseline resolution of 17 cannabinoids is demonstrated.  Different approaches to method development, depending on the goal of the analysis are discussed, including using speed of analysis as a means for changing selectivity to improve resolution of critical pairs as needed. Additionally, the resolution of a specific critical pair of THC isomers is optimized using a ternary mobile phase.<br/>

HPLC method development strategies for achieving baseline resolution of 17 cannabinoids

2019 Fall National Meeting

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