Iron is the most abundant transition metal in the Earth's crust. New catalytic transformations where precious metal catalysts are replaced by nonprecious metals like iron allow for cheaper and more sustainable processes which are of high importance in modern organic chemistry research. In the course of our studies, an efficient and selective oxidation of phenols and anisoles was accomplished using inexpensive iron catalyst and peroxide in the presence of an acid. Moderate to high yields were achieved for a variety of substrates bearing electron-withdrawing and electron-donating groups. Our approach is complimentary to most recent methods that rely on the use of an expensive catalyst (Pd, Ir) and/or require the prefunctionalization of a substrate.

Iron-catalyzed site-selective oxidation of phenols and anisoles

2019 Fall National Meeting

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