The controlled fragmentation of covalent bonds is an enabling capability for drug delivery. It helps if the bond-making steps are also efficient. We have recently expanded the range of connection and disconnection processes involving biologically-relevant nucleophiles and electrophiles designed for fast on-rates and widely controllable rates of cleavage. Applications to hydrogels for the entrainment and release of biomolecular cargo will be featured but other uses may also be discussed, depending on how things go in the months between the submission of this abstract and the date of the symposium.

Nucleophile-triggered cleavable linkage chemistry: Fundamentals and applications

2019 Fall National Meeting

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