The sultam moiety is found in a variety of biologically active molecules and they have found widespread applications in the pharmaceutical sector. Thus, methods to rapidly prepare sultam-containing molecules are of significant importance. Carboamination of alkenes is a succinct strategy to access sultam containing drug-like scaffolds allowing for the formation of key carbon−carbon and carbon−nitrogen bonds in a single operation. Our group's recent efforts in alkene carboamination led us to discover a route to sultam-containing molecules. This work will disclose the optimization, scope, and synthetic utility of the prepared sultam products.

Carboamination strategy for sultam synthesis enabled by photoredox catalysis

2019 Fall National Meeting

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