Single-particle cryo-electron microscopy (Cryo-EM) complements X-ray crystallography and NMR for studying the structural biology of challenging systems, particularly for large protein-protein complexes. Recent technical advances in data collection and data processing have resulted in a significant progression resolution routinely achievable by Cryo-EM. As the current limits are technological rather due to physics, cryo-EM will likely continue to progress as a field.<br/>The implications for drug discovery and development are perhaps the most exciting. At Genentech, we have established a cutting edge Cryo-EM laboratory to support large molecule, small molecule, and basic research projects. To date, our facility represents the largest cryo-EM effort in Pharma, worldwide. Our goal is to use in-house Cryo-EM to catalyze drug discovery. Thus far, we have used cryo-EM to enable high-resolution structures of several membrane protein complexes bound to antibodies and small molecules and we are currently moving our attention towards high-resolution structures of challenging &lt;100kDa protein complexes refractory to protein crystallography.

Supporting drug discovery and research at Genentech with cryo-EM

2019 Fall National Meeting

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