Inspired by the responsive behavior of the fibrous, ECM architecture, we have expanded our interest in low molecular weight gels (LMWGs) to the design of dynamic gel assemblies that utilize high molecular weight polymers as reinforcing additives. Via this approach, we demonstrate modular gel mechanics tailored by the nucleation behavior of the self-assembled, molecular gel. Guiding principles of the structural interplay dictated by component interactions, polymer chain conformation, and concentration were revealed. Our ultimate goal is the design of reconfigurable and responsive composites derived from LMWG fiber assemblies, transitioning from gel-state fundamentals to solid-state composites. Toward that end, we explored how the molecular gel network influences the mechanics of the polymer matrix. Insight into restrictions on chain mobility, and decoupled gel network and matrix stability are highlighted, moving closer to the realization of solid-state switchability. New thrust areas in light guide assemblies, and therapeutic immobilization and tailored release are envisioned utilizing these polymer-gel systems. Fiber constructs are prevalent in natural systems, from collagen fiber networks in tendon to tough, spider silk fibers. Recent innovations in multilayer co-extrusion technologyhave translated to the fabrication of melt-extruded fiber-reinforced composites. Distinct advantages of this modular approach over other traditional techniques include scalability, environmentally-friendly conditions, and the ability to obtain cross-sectional dimensions on the nanoscale. Here, we describe the mechanics and structural features of biologically-relevant, reinforced hydrogels via an in situ approach. This manufacturing strategy allows for strategic control of hydrogel architecture, fiber alignment and loading, compressive stability and stiffness. Promising results related to cell adherence and growth, and controlled degradation rates are highlighted for these extruded hydrogel scaffolds.

Nature-inspired strategies for reinforcement of polymer gels and composites

2019 Fall National Meeting

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