Nickel-catalyzed small molecule transformations have found wide applications in organic synthesis. Many of the recent developments in organonickel catalysis involve nickel-mediated bond activations including C-H, O-H, and N-H bonds. These bond activation processes provide new approaches to utilize readily available small molecule building blocks towards atom-efficient chemical synthesis. Herein we report  observations on nickel-mediated stoichiometric activation of N-H and O-H bonds that proceeds under mild conditions and leads to discrete Ni(II) complexes with corresponding anionic N- and O-donor ligands. We present a mechanistic hypothesis that involves metal-ligand cooperation and could lead to rational design of new strategies in nickel-catalyzed transformations of amines and alcohols.

Nickel-mediated activation of N-H and O-H bonds

2019 Fall National Meeting

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