<br/>Chemical registration systems have been in use in the biopharma, agro and chemical industries for many years in order to record a company's small molecule assets, determine their novelty, and ensure adherence to chemical business rules. However, many of these system are reaching the end of their life as they are not able to adequately cope with newer challenges such as a wider range of chemical modalities (e.g. large peptides, therapeutic antibodies, advanced materials), enhanced stereochemical representation, much higher volumes of data, collaborations, and integration of heterogeneous chemical data resulting out of company mergers and acquisitions.<br/>Consequently, many companies are investigating a replacement of their legacy chemical registration system, or are already actively replacing it. When moving to the next generation chemical registration system correct migration of legacy chemical data poses a particular challenge, both in the sense of formal and technical correctness, and in the 'semantic' sense of which actual compound is meant by a given compound record in the legacy system.<br/>In our presentation we will discuss the specifics of common chemical database technologies employed in chemical registration systems as well as their differences, highlight the caveats this presents for chemical database and registration system migrations, share experiences gained from a variety of migration projects, and provide guidance how to overcome the difficulties.<br/>

Challenges in chemical registration system migrations, and how to deal with them

2019 Fall National Meeting

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