Two-dimensional liquid chromatography (2D-LC) has been gaining more and more attentions from both academia and industries thanks to the evolution in instrumentation and software. There are three different modes of 2D-LC: heart-cutting, comprehensive and high-resolution sampling. Among which, comprehensive and high-resolution sampling can be extremely powerful in profiling complex samples. Here, we would like to focus on these two modes, introduce automated solvent modulation (ASM) feature and give some examples demonstrating how complex samples are successfully analyzed.

Optimizing separation for complex samples using two-dimensional liquid chromatography

2019 Fall National Meeting

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