Recently, the pharmaceutical industry has increased interest in continuous flow processes because of drastically shortened reaction time, effective heating with tubular reactors, minimized hazardous chemical exposure to the user, and ultimately, lower production costs. Development of continuous multi-step syntheses of nucleoside antivirals including tiazofurin, taribavirin, and ribavirin has been performed on AutoSyn<sup>TM</sup>, our modular flow chemistry hardware. After development as individual processes, the three syntheses were performed consecutively over 13 hours. Reconfiguration of AutoSyn between each process was accomplished in less than two hours. The reaction output of each process was measured by on-line LC-MS and in-line <sup>1</sup>H-NMR, confirming the successful preparation of the three targets and that no carry over was observed from process to process.

Continuous synthesis of three nucleoside antivirals in one day on an automated flow chemistry system

2019 Fall National Meeting

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