The engagement of pseudo-halides by nickel catalysis has expanded the utility of cross-coupling reactions by broadening the range of available coupling partners. A nickel-catalyzed cross-electrophile coupling reaction of mesylates to generate cyclopropanes has been developed. This is the first example of a cross-electrophile coupling reaction between two alkyl coupling partners as well as the first example of a cross-electrophile coupling reaction between two mesylates. Various substitution patterns have been examined resulting in the generation of both monosubstituted and disubstituted cyclopropanes. This method has also been extended to benzylic substrates affording aryl cyclopropanes.

Nickel-catalyzed cross-electrophile coupling reaction of mesylates for cyclopropane synthesis

2019 Fall National Meeting

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