Chemiluminescence techniques are considered one of the most sensitive methods for detection and imaging applications. Chemiluminescent probes with near-infrared emission are particularly useful for in vivo imaging, since light at such wavelength has greater penetration through organic tissue. So far, only several reports described chemiluminescent probes for in vivo imaging based on an energy transfer from a chemiluminescent precursor to a nearby emissive dye. Here, we describe the development of chemiluminescence probes with direct mode of near-infrared emission, that are suitable for many bio-applications. We designed and synthesized probes capable of imaging biologically relevant markers in vivo. We anticipate that our strategy for obtaining near infrared chemiluminescent probes will open new doors for further exploration of complex biomolecular systems using non-invasive intravital chemiluminescence imaging techniques.

Near-infrared chemiluminescence probes for detection and imaging

2019 Fall National Meeting

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