Bisphenol A (BPA) is an organic synthetic compound used as a starting material for the synthesis of plastics, mainly certain polycarbonates and epoxy resins, which both have been utilized as food contact materials. BPA is an endocrine disrupting chemical with estrogenic activity and is listed under Proposition 65 as a substance causing female reproductive toxicity. Due to exposure concerns for small children, BPA-based materials are no longer to be used in baby bottles, sippy cups, and infant formula packaging in the US, EU or Canada.<br/><br/>Low-level analysis of BPA is quite challenging because it requires careful control of laboratory contamination and elimination of any potential BPA sources from reagents and other materials. We developed and validated a simple, reliable, and cost-effective approach to determine BPA in beverage, food, infant formula, feed and dietary supplement matrices. The methodology combines a salting-out assisted liquid/liquid extraction with acidified acetonitrile and freeze-out removal of co-extracted lipids before the analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in negative electrospray ionization mode. The validated limits of quantification range from 0.3 µg/L in beverages to 5 µg/kg in very complex matrices, such as feed or botanical extracts. The method was approved AOAC First Action Official method 2017.15 for the determination of BPA in commercially packaged ready-to-consume carbonated and noncarbonated water and non-alcoholic beverages.

Reliable analysis of bisphenol A in beverage, food, infant formula, feed and dietary supplement matrices

2019 Fall National Meeting

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