Single chain polymeric nanoparticles (SCNPs) are water-soluble polymers that fold into a compact structure that resembles a folded polypeptide. By integrating one or multiple transition metal catalysts within the SCNP structure an artificial metalloenzyme can be created. But unlike naturally occuring metalloenzymes, catalytic SCNP can perform a wider range of reactions, leading to efficient transformations not found in nature. This talk will focus on structure-function relationships in these artificial metalloenzymes, similarities and differences with their naturally occuring counterparts, and their potential applications. The supramolecular binding capability of the SCNP allows their reactions to be performed at high dilution, which is particularly useful for intracellular organic synthesis of bioactive compounds as well as biolabeling where the target is present in low concentrations.

Single chain polymeric nanoparticles containing transition metals as artificial metalloenzymes

2019 Fall National Meeting

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