We present here a <i>de novo</i> synthetic study towards a family of 11-deoxylandomycin natural products, which exhibit significant biological activities. The signature step is represented by the convergent and stereoselective assembly of 2,3,6-trideoxygly moiety based on the use of sequential asymmetric transition metal catalysis. This method was used for the collective synthesis of various landomycin natural products as well as their synthetic analogs.

<i>De novo</i> synthetic study towards 11-deoxylandomycins

2019 Fall National Meeting

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De novo synthetic study towards 11-deoxylandomycins