Saussurea costus, commonly known as costus, has been part of the traditional Chinese and Indian medicine ever since antiquity. The medicine, which is mainly prepared out of the root, has been shown to contain several sesquiterpenoid compounds like (–)-dehydrocostus lactone (1), which is considered to be one of the most bioactive compounds in this radix. We have recently developed a enantioselective approach to 1, using a domino ring-closing-metathesis reaction to construct triene 2, as core motif, and a highly diastereoselective aldol reaction with chiral ester 3 and aldehyde 4.

Enantioselective approach to (–)-dehydrocostus lactone by a domino ring-closing-metathesis strategy

2019 Fall National Meeting

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