Currently, drugs, imaging agents and other payloads are administered through the mouth are delivered in a static function. Thus, a large portion of the active components are not absorbed necessitating larger doses which induce undesirable side effects. Chemically powered micromotors are autonomously propelled small-scale structures which can increase retention time in the gastrointestinal tract (GI) to promote higher absorption. Micromotors utilize the robust reaction of magnesium with biofluids to propel, lodge into and retain on tissues while pH-sensitive coatings endow them the ability to localize within different areas of the GI tract. Our results have shown that active micromotor delivery strategies prove much more effective than static particle or even free drug analogs opening the door towards more efficient targeted therapies.<br/>

Micromotors as targeted payload delivery platforms

2019 Fall National Meeting

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