Since its creation by Pfizer scientists and introduction by the Pistoia Alliance, HELM (Hierarchical Editing Language for Macromolecules) notation has been increasingly adopted as an industry standard for biologic sequence representation and registration. Scientists can now save their biologic sequences in an exchangeable format rather than that of their own organization. By providing a free-to-use sketcher, the release of an open source HELM web editor has helped expand HELM adoption.<br/> <br/>Various informatics vendors have added HELM notation support, often additionally including monomer library management. HELM has the ability and flexibility to represent various types of complex macromolecules. Given the variety of custom notations in use, many nuanced specifications are required for production use. With the adoption of HELM notation in its Chem and Bioinformatics products, Scilligence has been assisting its adoption and has encountered a great deal of “real-world” scientific data. In this presentation, our progress with the HELM representation, data integration, and our efforts to ease incorporation of legacy data will be summarized.

Current progress in HELM representation, integration, and data migration

2019 Fall National Meeting

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