UV irradiation is a major reason of DNA damage and skin cancer. ROS generation is induced by the UV exposure by UVA excitation for prolonged time. For the goal of developing long-lasting antioxidants that can penetrate skin, we have designed a ROS-initiated protective (RIP) reagent. It reacts with ROS, self-cyclizes to release a natural product, apocynin, known to inhibit NOX oxidase enzymes. A key phenol on the compound controls ROS-initiated cyclization. The RIP reagent was not cytotoxic to the healthy fiberblast cells, apocynin was released only in cells treated with UVR, and the reagent prevented UV-induced cell death. The reagent was more effective than administration of a catalase antioxidant. This chemistry platform will expand the types of ROS-activated motifs. Our data demonstrate that ROS-induced release an inhibitor of NOX oxidases has potential for use as a long-acting sunscreen.

Novel ROS-initiated self-cyclizaing antioxidant protects against UV damage by NOX inhibitor releasing process

2019 Fall National Meeting

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