Sugar phase-separated hierarchical arrays with lamellar and hexagonal morphologies that encode biological recognition in cell membrane mimics are among the most complex architectures yet discovered in soft matter.<br/>Atomic force microscopy images and their associated fast Fourier transforms (FFTs), along with complementary molecular modeling, are analyzed to address the question of what architectures program enhanced glycan function of Janus glycodendrimers (JGDs) vesicles. This methodology reveals that a complex hierarchical self-organization of sugar moieties arranged into lamellar and hexagonal nanophase-separated periodic arrays are responsible for the enhanced activity compared with glycodendrimersomes (GDSs) where sugars are densely packed and do not exhibit nanomorphologies.

Diffraction-like methodologies discover encoded biological recognition in bicomponent cell membrane mimics

2019 Fall National Meeting

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