Melokhanine E has a unique scaffold containing three contiguous stereocenters in a spiro-indolinone hexacyclic skeleton, and possesses potent biological activity.  Reported MIC’s show intriguing biological activity with greater potency against Gram-negative bacteria (<i>P. aeruginosa</i>, 2 mM) than Gram-positive bacteria (<i>E. faecalis</i>, 5 mM).  We have proposed a 10-step synthesis for melokhanine E with the ability to diversify for synthesis of analogues.

Synthesis of melokhanine E

2019 Fall National Meeting

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