Biopolymer such as peptide or DNA consists of identical backbone structure and various side chain structures in perfectly controlled sequence. The fact that such natural polymers give well-defined high ordered structures and express functions on the basis of the defined sequence indicates sequence is a crucial structural factor. On the other hand, vinyl copolymers consisting of variety of comonomer units have been utilized for many types of materials, but the sequence is not controlled and the properties been tuned by the averaged composition ratios.<br/>We have developed a methodology to control alternating sequence of common monomer units via selective cyclopolymeriation of a divinyl monomer and cleavage of the resultant cyclo-spacer. In this work, we newly designed a divinyl monomer consisting of acrylate and acrylamide connected through two activated ester bonds. The design allows synthesis of alternating sequence copolymers consisting solely of acrylamide units by addition of amine for cleavage of the two esters in the resultant cyclopolymer. One of the pendant groups in the alternating sequence is derived from the added amine and more than 10 kinds of alternating copolymers were obtained. These copolymers showed unique properties in solution and bulk due to the alternating sequence.

Alternating sequence copolymer consisting solely of acrylamide units: Strategic monomer design and sequence driven properties

2019 Fall National Meeting

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