Langmuir science teaches everything: molecular machine operation, nanocarbon synthesis & life regulation. This concept can be realized at dynamic two-dimensional medium such as thin films at the air-water interface, i.e., Langmuir monolayer because this medium possess both features of bulk and molecular dimension. For example, we successfully manipulated molecular machines at the air-water interface upon bulk (10-100 cm size) motion of the entire monolayer and realized “capture and release” of aqueous guest molecules using molecular machine, steroid cyclophane. In addition, mechanically controlled chiral recognition of amino acid and discrimination of nucleosides by the supramolecular monolayer was successfully demonstrated.<br/>As Langmuir protocol for nanocarbon synthesis, a new bottom-up method for carbon nanosheet fabrication using a newly designed anisotropic carbon nanoring molecule, will be also presented. The carbon nanoring was self-assembled at a dynamic air-water interface with a vortex motion to afford molecular nanosheets, which were then carbonized under inert gas flow. Their nanosheet morphologies were retained after carbonization, which has never been seen for low-molecular weight compounds. Furthermore, adding pyridine as a nitrogen dopant in the self-assembly step successfully afforded nitrogen-doped carbon nanosheets containing mainly pyridinic nitrogen species.<br/>For life regulation, we demonstrate the regulation of myogenic differentiation on fluid substrates by using a liquid-liquid interface as a scaffold. C2C12 myoblast cells were cultured using water−perfluorocarbon (PFC) interfaces as the fluid microenvironment. We found that, for controlled in vitro culture at water−PFC interfaces, expression of myogenin, myogenic regulatory factors (MRF) family gene, is remarkably attenuated even when myogenic differentiation was induced by reducing levels of growth factors, although MyoD was expressed at the usual level (MyoD up-regulates myogenin under an elastic and/or viscoelastic environment.

Langmuir science teaches everything: Molecular machine operation, nanocarbon synthesis, and life regulation at liquid interfaces

2019 Fall National Meeting

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