Enzymatic reactions and noncovalent interactions are two fundamental features of cells. Enzymatic noncovalent synthesis (ENS), a process that integrates enzymatic reactions and supramolecular (i.e., noncovalent) interactions for spatial organization of higher-order molecular assemblies, represents an emerging research area at the interface of physical (e.g., chemistry, physics, and nanotechnology) and biological sciences (e.g., structural biology, biochemistry, and cell biology). This talk will focus on the biological functions of peptide assemblies made from ENS. For example, pericellular and/or intracellular ENS selectively inhibits cancer cells and tumor growth; subcellular ENS delivers drugs and transfects gene expression into mitochondria; intercellular ENS enables cell morphogenesis (i.e., a 2D cell sheet become 3D cell spheroids). These studies have illustrated the use of supramolecular processes of peptides to control cellular functions for biology and medicine.

Enzymatic noncovalent synthesis (ENS) for peptide assemblies

2019 Fall National Meeting

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