We are developing nanoparticle catalysts whose structure and function mimic those of enzymes. These ‘nanozymes’ use hydrophobic monolayers on gold nanoparticles to encapsulate transition metal catalysts (TMCs), The monolayer both protects the TMC and controls access to the ‘TMC ‘active site’. In our research we are employing these nanozymes to perform bioorthogonal chemistry in living systems, providing access to new modalities for biomedical applications. We will discuss the engineering of these systems to replicate key enzymatic properties, as well as applications of nanozymes as therapeutic and imaging agents.

Nanoparticles and polymer-based nanozymes: Harnessing the power of transition metal catalysis for bioorthogonal chemistry

2019 Fall National Meeting

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