Near-infrared (NIR) light-induced photothermal therapy (PTT) has attracted much attention as an alternative to traditional cancer therapy due to its minimal invasiveness and selective localized treatment. It can lead to the killing of cancer cells using PTT agents that can absorb and convert NIR light to heat in the tumor cells.<br/>Herein, we report the fabrication of a fiber system for chemo-photothermal therapy composed of poly (D,L-lactic-co-glycolic acid) (PLGA) hollow fiber. An anticancer drug is encapsulated into core of the fiber. The shell containing gold nanorods (AuNRs) not only prevents unexpected release of the drug but also serves as a NIR light-absorbing PTT agent to construct NIR light-triggered on-demand drug release. Under NIR irradiation, AuNRs embedded in the shell produces heat to make the local temperature of the fibers higher. When NIR irradiation is switched off, the inactivity of the PTT agent will pause the segmental movement of the chains, which stops the release of the drug. This segmental switching of the polymer chains in response to the on–off operation of NIR light enables a repeated and precise release of the drug in an on<b>-</b>demand manner, causing the considerable improvement of antitumor activity in combination with the hyperthermia effect endowed by the PTT agent.

PLGA fiber containing AuNRs for on-off controlled anticancer drug release system

2019 Fall National Meeting

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