Continuous flow chemistry continues to see adoption in industry across a range of materials, like drug API's, fine chemicals, nanoparticles, and polymers. As we have transferred polymerization processes to manufacturers, we have started seeing common issues arising. So far, these have all been with niche product lines with production turnovers in the order of 100kg/y to 1t/y, but appear across several different polymerization techniques. ● Lower monomer conversion levels in larger diameter tubes. ● Residue coatings after extended runs. ● Feedstock ageing. The successful deployment of flow chemistry processes at commercial scale requires the effective resolution of these and other process related challenges. This presentation will present relevant experiences from our laboratories.

Continuous flow polymerizations: Lessons from the factory floor

2019 Fall National Meeting

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