Polymerization induced self-assembly (PISA) is a relatively new synthetic method that results in one-pot morphologically-controlled polymeric nanostructures. Conceptually, a homopolymer is chain-extended with a co-monomer in a solution in which they are both soluble. The second polymer, upon chain-extension, will gradually become insoluble, triggering <i>in situ</i> self-assembly. Most PISA methods have been reversible addition-fragmentation chain-transfer polymerization (RAFT-PISA), however recent developments have led a variety of PISA reaction types. PEG-b-PCL are of synthetic interest for their biocompatibility and potential for drug-loading. However, current PISA approaches cannot yield PEG-b-PCL. Here we present the progress of the development of a new PISA method: Ring-opening PISA (RO-PISA). Using a PEG initiator and caprolactone as the co-monomer with the aid of catalytic methods in a selective solvent, RO-PISA can be accomplished. Polymerization kinetics will be monitored with MALDI, NMR, and SEC. Structural evolution will be monitored with cryo-TEM and DLS.

ROPISA: Ring-opening polymerization induced self-assembly

2019 Fall National Meeting

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