The fatty acid esters of 3-monochloropropane 1,2-diol (3-MCPD) are a group of thermal processing-induced toxicants. The absorption, distribution, metabolism, and excretion conditions of 3-MCPD esters need to be investigated to better clarify their possible toxicological effects and mechanisms. In this study, the kinetic parameters of 3-MCPD dipalmitate in Sprague Dawley (SD) rat plasma were determined using ultraperformance liquid chromatography−triple quadrupole mass spectrometry (UPLC-Q TOF MS). As the results, the metabolic parameters of 3-MCPD dipalmitate, including a Cmax of 135.00 ng/mL, a T1/2 of 3.87 h, a Tmax of 2.5 h, an MRT of 5.08 h, a CL of 3.50 L/h/g, and a Vd of 21.34 L/g have been determined. Besides, a total of 17 metabolites were tentatively identified, and 16 of them were reported for the first time. Furthermore, these metabolites were examined for their presences in rats’ liver, kidney, testis, brain, spleen, thymus, intestine, plasma, feces, and urine samples 2, 6, 12, 24, and 48 hours after orally administrated of 3-MCPD dipalmitate. The results represented that 3-MCPD dipalmitate could be absorbed and distributed to organs and tissues, including the brain and testis. It could also be metabolized to other 3-MCPD diesters, 3-MCPD monoesters, glycidyl ester, 3-MCPD or endogenous substance conjugation metabolites, as well as excreted through both feces and urine.

Toxicokinetics and metabolism of 3-monochloropropane 1,2-diol dipalmitate in Sprague-Dawley rats

2019 Fall National Meeting

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