Fluorescent gold nanoclusters conjugated with 2A3 antibody (2A3-AuNCs) were developed for evaluation of cancer progression and inhibition of cancer cell proliferation. The 2A3 antibody can specifically bind onto carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) on the cancer cell surface to decrease cancer cell proliferation, metastasis and angiogenesis. In this study, we can target CEACAM6 overexpressed breast cancer cells by applying target-specific 2A3-AuNCs as fluorescent probes. After binding with CEACAM6, the fluorescence changes of 2A3-AuNCs were measured and calculated to simulate their kinetics for assessment of breast cancer progression. Moreover, the fluorescence imaging and fluorescence change of 2A3-AuNCs were applied to investigate their inhibition of breast cancer cell proliferation. Overall, the target-specific 2A3-AuNCs were demonstrated as a promising fluorescent probe for evaluation of cancer progression and inhibition of cancer cell proliferation.

Evaluation of cancer progression and inhibition of cancer cell proliferation by using target-specific 2A3 antibody-conjugated gold nanoclusters

2019 Fall National Meeting

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